Selected Past and current clients

Wireless power transfer

What is WPT?

Wires connect, but they also limit both physically and situationally. The Etherdyne technology provides wireless meaningful power to entire spaces, not just “charging” or “touch power”1,2. In many environments, the cost of wiring installation can be as expensive as the components themselves. However, often times we find ourselves in need of relocating some components but find out that the wiring just isn’t in quite the right place.

In today’s professional lighting environment, we are all bound by similar constraints on projects large and small, such as museums, galleries, restaurants, and retail. For many years, track power distribution has been widely used to address the challenge of flexibility for changing environments such as exhibits, and retail season shifts. Although, it is an intensely functional solution, it is hard to make it “pretty”. ETI removes wiring from the power delivery systems and provides and ecosystem that offers mobility of clients within the transmission zone and complete flexibility in terms of what is powered3,4. By eliminating visible components, the ETI platform works equally well in “dry” applications and “wet” zones with higher IP ratings. The ETI system is hugely scalable and can be designed to extend over hundreds of meters.

How did inGenuyX help?

The inGenuyX team has been assisting Etherdyne Technologies in evaluating the safety of one of the ETI systems used in the AirBrite Universal Wireless Lighting Systems5. AirBrite kits allow The inGenuyX team assisted Etherdyne Technologies in evaluating the safety of one of the ETI systems used in the AirBrite Universal Wireless Lighting Systems5. AirBrite kits allow creating lighting arrangements used in Christmas displays, floral decorations, or book shelfs without the complications of cords or wirings. To address the safety concern, inGenuyX team performed comprehensive numerical simulations of the wireless power transfer system together with various virtual body models. The performance of the WPT system in terms of the specific absorption rate (SAR) was evaluated under different scenarios and postures. Attached figure shows two representative examples of such numerical analysis, where the SAR maps are evaluated for two plausible scenarios (a) when a man (Duke virtual body model) is working at the table with AirBrite and (b) when a woman (Ella virtual body model) is standing next to a display with AirBrite.

References

  1. https://www.etherdyne.net/
  2. https://darcawards.com/portfolio/eti-etherdyne-power-transmission-etherdyne-technologies/
  3. Moffatt, Robert A. “Geometric Quantities Characterizing Wireless Power Transfer Between a Resonator and Resonant Dipoles.” 2019 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2019.
  4. Moffatt, Robert A., et al. “A Distributed, Phase-locked, Class-E, RF Generator with Automatic Zero-Voltage Switching.” 2019 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2019.
  5. https://www.airbritelighting.com/

Treating cancer with electric fields: Lifebridge 10000

Lifebridge 10000 – story

As a tribute to his wife Laurie who suffered from cancer, Peter Travers discovered that the treating fields therapy (TTFields) is FDA approved for glioblastoma. But he learned it would not be available to treat people with cancer for 10 or more years. In order to accelerate the research and help his wife, Peter formed a team of friends and family and founded Lifebridge 10000. They developed a new TTFields device that met the standards of current research. Laurie wore the TTFields 12 hours a day. Over the next 12 to 18 months, wherever the TTFields was applied, the cancer was stable or reduced, but unfortunately the tumor continued to spread outside the TTFields’ range. Laurie lived an additional three years because of her husband’s TTFields device. 1

Lifebridge 10000 – mission

The company’s mission is to accelerate the development of cancer treatments. The Lifebridge 10000 team continues to research and develop its TTFields device for future FDA approval. The device will be used for advanced cancer patients with metastatic disease and will cover two or more locations on the body at the same time for faster recovery and to prevent rapid tumor spread.

How does Treating Fields Therapy (TTFields) work?

TTFields is a successful, non-invasive antimitotic oncology treatment that has been approved by the U.S. FDA for the treatment of glioblastoma. An array of electrodes is placed on the skin around the cancer area. Each electrode delivers a low intensity (1-3 V/cm) alternating electric field in the frequency range of 100 to 300 kHz specific to the cancer cell types. The progression-free survival rate at six months and the overall response rate were increased for TTFields-treated patients compared to chemotherapy, respectively. It was shown that TTFields have an effect only on dividing cell, while no effect on the quiescent cells which inhibit the metastatic spread or growth of the tumor2. Exemplary partial radiological response to NovoTTF therapy in a patient with recurrent glioblastoma is shown below. T1-weighted axial MRI images with contrast before (left panel) and after two years of NovoTTF therapy (right panel).2

Sim4LIfe simulation

The inGenuyX team has been assisting Lifebridge 10000 in its mission to obtain FDA approval for its TTFields device by modeling the device and performing electromagnetic simulations to meet requirements. A lung cancer electrode array was modeled and studied using SIM4LIFE. For a realistic in silico scenario, a body model, Duke (IT’IS Foundation, Zurich, Switzerland), was employed. More than 100 electrodes meeting the specifications given by the Lifebridge 10000 have been designed. The Electric field magnitue (V/cm), specific apsorption rate (W/kg) and power density (mW/cm3) for different input voltages ranging from 140V to 200V peak-to-peak were studied as shown in Figure below. The maps and the field strength changed with the position of the activated electrodes and with the input voltage.

References

  1. http://www.lifebridge10000.com/
  2. Davies AM, Weinberg U, Palti Y. Tumor treating fields: a new frontier in cancer therapy. Annals of the New York Academy of Sciences. 2013;1291(1):86-95.

Adona Medical: Improving Care for Heart Failure Patients

What is heart failure?

Heart failure, also known as congestive heart failure (CHF), is a chronic condition, where heart fails to supply required amount of blood and oxygen to the body, which results in fatigue, shortening of breathing and rapid heartbeat. It is a complex and progressive condition that impacts approximately 6.5 million patients in the United States and as many as 26 million patients globally1. The ultimate goal of treating heart failure is to improve the ability of the heart to pump blood. In addition to improving the pumping function of the heart, it is also important to treat the symptoms. Unfortunately, the treatment options are limited, and many patients are poorly managed with guideline-directed pharmaceutical approaches. These patients generally suffer from impaired functional independence, poor quality of life, and may experience frequent heart failure associated hospitalizations.2

What is Adona Medical?

Adona Medical offers a next-generation heart failure management platform. Adona’s platform will overcome the shortcomings of existing treatment options and enable providers to improve care for heart failure patients. The company’s innovative solution was distinguished by Excelestar Ventures, AMED Ventures, and Cormorant Asset Management investors and received a $22M Series A financing in September 2020. With this support, the company is now focused on advancing product development, pre-clinical testing, and expanding their team of world-class scientists and engineers to bring their next-generation heart failure management platform to the market.

How does inGenuyX help?

The inGenuyX team has been assisting Adona Medical in its mission to obtain FDA approval for their heart failure management system. A compressive and systematic in silico analysis of the exposure of human body to the electromagnetic radiation is necessary to assess potential risks associated with the device usage. To model a realistic scenario, Sim4Life3 simulation software and various virtual human body models were used4. The detailed human body models include all the important tissues and can be positioned in any realistic body posture. Some of the most important characteristics associated with the body exposure to electromagnetic radiation are electric field (E), magnetic flux density (B), and specific absorption rate (SAR).

References

  1. Benjamin, Emelia J., et al. “Heart disease and stroke statistics—2018 update: a report from the American Heart Association.” Circulation 137.12 (2018): e67-e492.
  2. Jackson, Sandra L., et al. “National burden of heart failure events in the United States, 2006 to 2014.” Circulation: Heart Failure 11.12 (2018): e004873.
  3. Sim4Life https://zmt.swiss/sim4life/
  4. ITIS Virtual Population https://itis.swiss/virtual-population/virtual-population/overview/

cochlear implants at 3T MRI

Hearing loss solutions

Hearing loss can take many forms, such as cholesteatoma, not being able to hear loud or high frequency sounds, being born with a hearing loss, having a malformed ear, having a hearing loss due to an ear infection, or only hearing on one side.

MRI and cochlear implants

MED-EL has built cochlear implants so that recipients can be safely scanned in an MRI system under certain conditions. This means that no additional surgery is required to undergo an MRI and there is no painful magnetic pull on the implant during the scan. Hearing systems can undergo MRI scans at 1.5 and 3.0 Tesla with the magnet in place. However, the power deposition induced by the MRI radiofrequency field at the implant must be investigated for a normal scanner operating mode.

optimal catheter design for Cardiac ablation

cardiac ablation

Cardiac ablation is a procedure that is used to treat abnormal heart rhythms (arrythmias) when pharmacologic treatments are ineffective. During this procedure, targeted radiofrequency pulses destroy a small area of heart tissue which is causing irregular heartbeats. Cardiac ablation is done using a thin, flexible tube called catheter inserted through the veins or arteries and advanced towards the heart. Electrical impulses are then used to induce the arrhythmia and local heating or freezing is used to ablate (destroy) the abnormal tissue.

How does inGenuyX help?

InGenuyX has been assisting the company in determining an optimum design for the catheter tube such that to maximize the power delivered to he targeted area and to minimize damage to the surrounding tissues. We use COMSOL simulation software to systematically analyze and optimize the design and dimensions of the catheter.

MRI RF coil safety evaluation

NORAS MRI products

NORAS MRI products GmbH [1] is an R&D company specialized in development, manufacturing, and distribution of radiofrequency coils and biopsy accessories for magnetic resonance imaging (MRI). NORAS has over 35 years of experience in MRI industry and internationally recognized for its customer-oriented service. The company offers a variety of self-developed MR coils for multifunctional applications for use with MRI scanners from leading manufacturers such as Siemens, GE Healthcare [2], and Philips.

how did ingenuyx help noras?

inGenuyX team has been helping NORAS with passing the safety tests required for their new product. Every new MRI coil product must adhere to certain industrial standards in terms of its safety during the MRI procedures before being allowed to go on the market. Some of the necessary procedures include RF coil heating evaluation under worst case placement scenarios. For this evaluation, inGenuyX measure the coil surface temperature before and after a dedicated pulse sequence with a thermal camera. Moreover, optical sensor temperature probes are applied in multiple coil locations and continuously monitored throughout the scanning procedure.

references

  1. https://www.noras.de/en/
  2. GE Healthcare https://www.gehealthcare.com

MRI RF coil safety evaluation

RF coil safety testing

inGenuyX team has been helping RF coil manufacturing companies with passing the safety tests required for their new product. Every new MRI coil product must adhere to certain industrial standards in terms of its safety during the MRI procedures before being allowed to go on the market. Some of the necessary procedures include RF coil heating evaluation under worst case placement scenarios. For this evaluation, inGenuyX measure the coil surface temperature before and after a dedicated pulse sequence with a thermal camera. Moreover, optical sensor temperature probes are applied in multiple coil locations and continuously monitored throughout the scanning procedure.

Wireless power transfer for mri

In MRI, wearable wireless receive coil arrays are a key technology goal. An MRI compatible wireless power transfer (WPT) system will be needed to realize this technology. An MRI WPT system must withstand the extreme electromagnetic environment of the scanner and cannot degrade MRI image quality. Together with GE healthcare, Simone Winkler developed a WPT system for operation in MRI scanners using new microelectromechanical RF (RF MEMs) switch technology2.

AI for real time SAR estimation

A key limitation to the high potential of ultra-high field MRI is the safety concern related to the nonuniform deposition of radiofrequency (RF) power in the body quantified by the specific absorption rate (SAR). Simone Winkler proposed an AI-based, exam-integrated, MRI safety prediction software facilitating the safe generation of UHF MR images3.

references

  1. GE Healthcare https://www.gehealthcare.com
  2. DOI: 10.1109/TMTT.2019.2902554
  3. DOI: 10.1109/ACCESS.2021.3118290

Location technology

Polte

Polte‘s patented positioning technology offers high resolution accurate and reliable asset end-to-end visibility tool. Polte allows seamless asset tracking with ultra-high precision on the factory floor, in the warehouse, and during the transportation to its next destination. This technology demonstrates industry leading performance improvement for all types of location (RTT, TOA, AOA), devices (Cat-1, Cat-M, 5G, NB-IoT), and on all 4G and 5G networks. Polte’s decades worth of know-how is the key to the ecosystem’s ability to enable 4G and 5G location, including z-axis using 5G.

Ingenuyx

inGenuyX has been helping with measuring technology testing and data gathering.

references

  1. https://www.polte.com/

MR:comp

Founded in 2004, MR:comp GmbH is a leading company for MR safety and MR compatibility testing of implants, instruments, and medical devices. They are an accredited laboratory (ISO 17025) for ASTM standard tests of MR safety and compatibility. They provide numerical simulations of electromagnetic fields, SAR, temperature distribution, and RF-induced heating of implants and instruments.

MR:comp is located in Ruhr area (Germany) and surrounded by a number of technical universities and well-known clinics which provides MRI experts and scanner availability ranging from 0.2T to 7.0T.

Moreover, the company is part of DIN, ISO, IEC, and ASTM standardization committees in the field of the development and optimization of MR testing methods.

References

  1. https://www.mrcomp.com/en/

NM robotic

Founded in 2013 and based in Linz / Austria and Los Angeles / CA, NM Robotic is dedicated to the autonmous vehicle market for hobbists and professionals. A combination of cost effective technology and superior performance gives NM Robotic its market leading competitive advantage. Superior performance, ease of integration and a professional supply chain throughout the world make NM Robotic the brand of your choice.

NM Robotic offers specialized expertise in the technology fields of

  • FPGA based mining of cyrpto currencies
  • Navigation and Control for UAVs and autonomous cars
  • Formal verification of cyberphysical systems in real time and offline
  • ndustrial cybersecurity for PLCs

How did ingenuyx help?

Bitcoin mining algorithm was implemented on FPGA using AWS cloud, code language OpenCL.

References

  1. http://www.nmrobotic.com/

Autonomous vehicles

For all autonomous vehicles currently on the road, or operated in the air as prototypes, the human remains in the loop and fully responsible therefore there is no true autonomy. One primary issue is to acquire a permit to fly or drive from a public authority such as the EASA or FAA for aviation, or the NHTSA, KBA for automotive which can only be based on proof that the automated or autonomous vehicle is in compliance with the relevant regulation e.g.; the traffic act or the rules of the air.

The Kontrol approach is deterministic, and gives transparent boundaries with regard to what is compliant. It is formal human and machine-readable language, geometric analytic interpretation of text, combined with reachability analysis which gives transparency of reachable/compliant space where a vehicle operates.

References

  1. https://www.kontrol.tech/