Selected Past and current clients

Wireless power transfer

What is WPT?

Wires connect, but they also limit both physically and situationally. The Etherdyne technology provides wireless meaningful power to entire spaces, not just “charging” or “touch power”^1,2. In many environments, the cost of wiring installation can be as expensive as the components themselves. However, often times we find ourselves in need of relocating some components but find out that the wiring just isn’t in quite the right place.

In today’s professional lighting environment, we are all bound by similar constraints on projects large and small, such as museums, galleries, restaurants, and retail. For many years, track power distribution has been widely used to address the challenge of flexibility for changing environments such as exhibits, and retail season shifts. Although, it is an intensely functional solution, it is hard to make it “pretty”. ETI removes wiring from the power delivery systems and provides and ecosystem that offers mobility of clients within the transmission zone and complete flexibility in terms of what is powered^3,4. By eliminating visible components, the ETI platform works equally well in “dry” applications and “wet” zones with higher IP ratings. The ETI system is hugely scalable and can be designed to extend over hundreds of meters.

How did inGenuyX help?

The inGenuyX team has been assisting Etherdyne Technologies in evaluating the safety of one of the ETI systems used in the AirBrite Universal Wireless Lighting Systems⁵. AirBrite kits allow The inGenuyX team assisted Etherdyne Technologies in evaluating the safety of one of the ETI systems used in the AirBrite Universal Wireless Lighting Systems⁵. AirBrite kits allow creating lighting arrangements used in Christmas displays, floral decorations, or book shelfs without the complications of cords or wirings. To address the safety concern, inGenuyX team performed comprehensive numerical simulations of the wireless power transfer system together with various virtual body models. The performance of the WPT system in terms of the specific absorption rate (SAR) was evaluated under different scenarios and postures. Attached figure shows two representative examples of such numerical analysis, where the SAR maps are evaluated for two plausible scenarios (a) when a man (Duke virtual body model) is working at the table with AirBrite and (b) when a woman (Ella virtual body model) is standing next to a display with AirBrite.

References

1. https://www.etherdyne.net/
2. https://darcawards.com/portfolio/eti-etherdyne-power-transmission-etherdyne-technologies/
3. Moffatt, Robert A. “Geometric Quantities Characterizing Wireless Power Transfer Between a Resonator and Resonant Dipoles.” 2019 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2019.
4. Moffatt, Robert A., et al. “A Distributed, Phase-locked, Class-E, RF Generator with Automatic Zero-Voltage Switching.” 2019 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2019.
5. https://www.airbritelighting.com/

Treating cancer with electric fields: Lifebridge Innovations

Lifebridge Innovations – story

As a tribute to his wife Laurie who suffered from cancer, Peter Travers discovered that the treating fields therapy (TTFields) is FDA approved for glioblastoma. But he learned it would not be available to treat people with cancer for 10 or more years. In order to accelerate the research and help his wife, Peter formed a team of friends and family and founded Lifebridge Innovations. They developed a new TTFields device that met the standards of current research. Laurie wore the TTFields 12 hours a day. Over the next 12 to 18 months, wherever the TTFields was applied, the cancer was stable or reduced, but unfortunately the tumor continued to spread outside the TTFields’ range. Laurie lived an additional three years because of her husband’s TTFields device. ¹

Lifebridge Innovations – mission

The company’s mission is to accelerate the development of cancer treatments. The Lifebridge Innovations team continues to research and develop its TTFields device for future FDA approval. The device will be used for advanced cancer patients with metastatic disease and will cover two or more locations on the body at the same time for faster recovery and to prevent rapid tumor spread.

How does Treating Fields Therapy (TTFields) work?

TTFields is a successful, non-invasive antimitotic oncology treatment that has been approved by the U.S. FDA for the treatment of glioblastoma. An array of electrodes is placed on the skin around the cancer area. Each electrode delivers a low intensity (1-3 V/cm) alternating electric field in the frequency range of 100 to 300 kHz specific to the cancer cell types. The progression-free survival rate at six months and the overall response rate were increased for TTFields-treated patients compared to chemotherapy, respectively. It was shown that TTFields have an effect only on dividing cell, while no effect on the quiescent cells which inhibit the metastatic spread or growth of the tumor². Exemplary partial radiological response to NovoTTF therapy in a patient with recurrent glioblastoma is shown below. T1-weighted axial MRI images with contrast before (left panel) and after two years of NovoTTF therapy (right panel).²

Sim4LIfe simulation

The inGenuyX team has been assisting Lifebridge Innovations in its mission to obtain FDA approval for its TTFields device by modeling the device and performing electromagnetic simulations to meet requirements. A lung cancer electrode array was modeled and studied using SIM4LIFE. For a realistic in silico scenario, a body model, Duke (IT’IS Foundation, Zurich, Switzerland), was employed. More than 100 electrodes meeting the specifications given by the Lifebridge Innovations have been designed. The Electric field magnitue (V/cm), specific apsorption rate (W/kg) and power density (mW/cm³) for different input voltages ranging from 140V to 200V peak-to-peak were studied as shown in Figure below. The maps and the field strength changed with the position of the activated electrodes and with the input voltage.

References

1. http://www.lifebridge10000.com/
2. Davies AM, Weinberg U, Palti Y. Tumor treating fields: a new frontier in cancer therapy. Annals of the New York Academy of Sciences. 2013;1291(1):86-95.

Adona Medical: Improving Care for Heart Failure Patients

What is heart failure?

Heart failure, also known as congestive heart failure (CHF), is a chronic condition, where heart fails to supply required amount of blood and oxygen to the body, which results in fatigue, shortening of breathing and rapid heartbeat. It is a complex and progressive condition that impacts approximately 6.5 million patients in the United States and as many as 26 million patients globally¹. The ultimate goal of treating heart failure is to improve the ability of the heart to pump blood. In addition to improving the pumping function of the heart, it is also important to treat the symptoms. Unfortunately, the treatment options are limited, and many patients are poorly managed with guideline-directed pharmaceutical approaches. These patients generally suffer from impaired functional independence, poor quality of life, and may experience frequent heart failure associated hospitalizations.²

What is Adona Medical?

Adona Medical offers a next-generation heart failure management platform. Adona’s platform will overcome the shortcomings of existing treatment options and enable providers to improve care for heart failure patients. The company’s innovative solution was distinguished by Excelestar Ventures, AMED Ventures, and Cormorant Asset Management investors and received a $22M Series A financing in September 2020. With this support, the company is now focused on advancing product development, pre-clinical testing, and expanding their team of world-class scientists and engineers to bring their next-generation heart failure management platform to the market.

How does inGenuyX help?

The inGenuyX team has been assisting Adona Medical in its mission to obtain FDA approval for their heart failure management system. A compressive and systematic in silico analysis of the exposure of human body to the electromagnetic radiation is necessary to assess potential risks associated with the device usage. To model a realistic scenario, Sim4Life³ simulation software and various virtual human body models were used⁴. The detailed human body models include all the important tissues and can be positioned in any realistic body posture. Some of the most important characteristics associated with the body exposure to electromagnetic radiation are electric field (E), magnetic flux density (B), and specific absorption rate (SAR).

References

1. Benjamin, Emelia J., et al. “Heart disease and stroke statistics—2018 update: a report from the American Heart Association.” Circulation 137.12 (2018): e67-e492.
2. Jackson, Sandra L., et al. “National burden of heart failure events in the United States, 2006 to 2014.” Circulation: Heart Failure 11.12 (2018): e004873.
3. Sim4Life https://zmt.swiss/sim4life/
4. ITIS Virtual Population https://itis.swiss/virtual-population/virtual-population/overview/